David S Williams Selected Research

Usher Syndromes (Usher Syndrome)

11/2011	Harmonin (Ush1c) is required in zebrafish Müller glial cells for photoreceptor synaptic development and function.
10/2011	The many different cellular functions of MYO7A in the retina.
7/2011	The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65.
2/2010	Function of MYO7A in the human RPE and the validity of shaker1 mice as a model for Usher syndrome 1B.
2/2008	Usher syndrome: animal models, retinal function of Usher proteins, and prospects for gene therapy.
5/2003	Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein.
1/2003	Screen for usher syndrome 1B mutations in the ovine myosin VIIa gene.

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David S Williams Research Topics

Disease

13	Neoplasms (Cancer) 01/2021 - 12/2010
10	Colorectal Neoplasms (Colorectal Cancer) 11/2022 - 12/2010
7	Retinal Degeneration 10/2017 - 12/2003
7	Usher Syndromes (Usher Syndrome) 11/2011 - 01/2003
6	Blindness (Hysterical Blindness) 01/2015 - 12/2004
5	Retinitis Pigmentosa (Pigmentary Retinopathy) 03/2015 - 12/2003
4	Colonic Neoplasms (Colon Cancer) 01/2021 - 10/2010
4	Alzheimer Disease (Alzheimer's Disease) 02/2014 - 02/2005
4	Deafness (Deaf Mutism) 10/2011 - 12/2003
4	type 1B Usher syndrome 12/2009 - 05/2003
3	Neoplasm Metastasis (Metastasis) 11/2022 - 07/2014
3	Inflammation (Inflammations) 12/2021 - 01/2011
3	Ciliopathies 01/2020 - 10/2010
3	Microsatellite Instability 10/2018 - 12/2010
2	Disease Progression 11/2022 - 03/2015
2	Adenocarcinoma 01/2020 - 11/2011
2	Obesity 11/2019 - 12/2005
2	Hypoxia (Hypoxemia) 03/2019 - 03/2018
2	Thrombosis (Thrombus) 01/2018 - 01/2011
2	Macular Degeneration (Age-Related Maculopathy) 10/2017 - 08/2008
2	Nephrotic Syndrome (Syndrome, Nephrotic) 06/2014 - 12/2013
2	Deaf-Blind Disorders 07/2011 - 05/2003
2	Agenesis of Cerebellar Vermis 02/2010 - 06/2006
2	Nonsyndromic Deafness 12/2009 - 08/2009
1	Lung Diseases (Lung Disease) 01/2022
1	Silicosis 01/2022
1	Chediak-Higashi Syndrome 01/2022
1	Hypertension (High Blood Pressure) 01/2022
1	COVID-19 12/2021
1	Leukemia 01/2021
1	Stomach Neoplasms (Stomach Cancer) 01/2021
1	Biliary Tract Neoplasms (Biliary Tract Cancer) 11/2019
1	Malignant Mesothelioma 10/2018
1	Mesothelioma 10/2018
1	Necrosis 03/2018
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2018
1	Breast Neoplasms (Breast Cancer) 06/2017
1	Leber Congenital Amaurosis 01/2014
1	Hydatidiform Mole (Molar Pregnancy) 01/2014

Drug/Important Bio-Agent (IBA)

16	Retinaldehyde (Retinal)IBA 01/2020 - 05/2003
14	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2003
5	Myosin VIIaIBA 10/2011 - 01/2003
4	Pharmaceutical PreparationsIBA 01/2021 - 01/2012
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2017
3	GTP Phosphohydrolases (GTPases)IBA 03/2015 - 03/2005
3	Carrier Proteins (Binding Protein)IBA 05/2009 - 09/2005
2	Calcibiotic Root Canal SealerIBA 11/2022 - 04/2012
2	Transcription Factors (Transcription Factor)IBA 11/2022 - 06/2006
2	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 10/2018
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 03/2018
2	Interleukin-6 (Interleukin 6)IBA 12/2021 - 01/2021
2	CytokinesIBA 12/2021 - 01/2021
2	Phosphotransferases (Kinase)IBA 01/2021 - 05/2009
2	MucinsIBA 01/2020 - 03/2018
2	LipidsIBA 12/2019 - 11/2019
2	Amyloid (Amyloid Fibrils)IBA 02/2014 - 11/2008
2	VaccinesIBA 12/2012 - 12/2010
2	Myosins (Myosin)IBA 10/2011 - 09/2004
2	AntigensIBA 12/2010 - 10/2010
2	Cadherins (E-Cadherin)IBA 04/2004 - 12/2003
1	ChromatinIBA 11/2022
1	Retinal Pigments (Pigments, Visual)IBA 01/2022
1	Silicon Dioxide (Silica)FDA LinkGeneric 01/2022
1	Capecitabine (Xeloda)FDA Link 01/2022
1	Bevacizumab (Avastin)FDA Link 01/2022
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2022
1	Antiviral Agents (Antivirals)IBA 12/2021
1	apolipoprotein A-I mimetic peptide 4FIBA 12/2021
1	Messenger RNA (mRNA)IBA 01/2021
1	tyrosine receptor (receptor, tyrosine)IBA 01/2021
1	regorafenibIBA 01/2021
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2021
1	Photosensitizing Agents (Photosensitizers)IBA 01/2021
1	Interleukin-11 (Interleukin 11)IBA 01/2021
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021
1	Tumor Suppressor Protein p53IBA 01/2020
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 11/2019
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2019
1	Oxygen (Dioxygen)IBA 03/2019
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2019
1	Ethylene Glycol (Monoethylene Glycol)IBA 11/2018
1	polytrimethylene carbonateIBA 11/2018
1	PromegaIBA 10/2018
1	VimentinIBA 03/2018
1	Indicators and Reagents (Reagents)IBA 03/2018
1	parthenolideIBA 01/2018
1	4- (4- dihexadecylaminostyryl)- N- methylpyridium (DiA)IBA 06/2017
1	Biological ProductsIBA 07/2014
1	SteroidsIBA 06/2014
1	SilverIBA 01/2014
1	Formaldehyde (Formol)FDA Link 01/2014
1	ParaffinIBA 01/2014
1	Complementary DNA (cDNA)IBA 01/2014

Therapy/Procedure

9	Therapeutics 12/2021 - 02/2008
3	Drug Therapy (Chemotherapy) 01/2022 - 07/2014
2	Transplantation 10/2017 - 03/2012
1	Adjuvant Chemotherapy 01/2020
1	Photochemotherapy (Photodynamic Therapy) 03/2019
1	Photothermal Therapy 01/2018
1	Lasers (Laser) 01/2018